No, there is no direct bus service between Joplin and Des Moines.

How long is the drive?

The drive takes about 6 hours 30 minutes.

No, there is no passenger rail service on this route.

What is the best route?

I-49 North to I-35 North is the most direct route.

Yes, it is a standard interstate route.

Joplin

Des Moines

Driving

Joplin to Des Moines

Updated: 28 May 2026

The journey from Joplin to Des Moines is approximately 400 miles, heading north through Kansas City. You will take I-49 North to Kansas City, then transition to I-35 North toward Des Moines. The drive typically takes 6 hours and 30 minutes. This route takes you through the heart of the Midwest, passing through major urban centers. It is a well-traveled interstate route.

Total Distance: 640 km driving distance; 550 km straight-line air distance.

Fastest Way

Driving via I-49 and I-35 is the fastest method, taking 6 hours 30 minutes.

Cheapest Way

Driving is the most practical and cost-effective way to travel.

Compare Joplin to Des Moines Routes

Driving

Direct

Duration

6 hours 30 mins

Avg Price

$75-$100 in fuel

Operator

Personal Vehicle

Route

I-49 North to Kansas City, then I-35 North to Des Moines.

Plan your Kansas City transit to avoid the morning or evening rush.

Travel Tips

Kansas City Traffic
Use the I-435 bypass to avoid the downtown Kansas City congestion.
Rest Stops
Ames, Iowa, is a great place to stop for lunch and fuel.
Navigation
Keep your GPS active to navigate the complex highway interchanges in Kansas City.
Weather
Iowa winters can be harsh; check road conditions before departing.
Booking
If staying in Des Moines, book hotels in the downtown area for walkability.

Safety Tips

Speeding
I-35 is heavily patrolled; maintain the speed limit at all times.
Fatigue
This is a long drive; take breaks every 2 hours to stay alert.
Vehicle
Check your coolant levels, as the long drive can put stress on your engine.
Emergency
Carry a roadside emergency kit, including jumper cables and a flashlight.