Key Largo
Key Largo
Charleston
Charleston
Flight Driving

Key Largo to Charleston

Updated: 28 May 2026

The journey from Key Largo to Charleston covers approximately 900 kilometers. The most efficient way to travel is by flying from Miami International Airport to Charleston International Airport. If you choose to drive, you will follow I-95 North through the entire East Coast. This route is a major interstate corridor. Expect a transition from the tropical Florida climate to the historic charm of the South Carolina coast.

Total Distance: 900 km driving distance; 800 km straight-line air distance.
Fastest Way
Flight from Miami International Airport to Charleston International Airport.
Cheapest Way
Driving is the most cost-effective for families or groups.
Compare Key Largo to Charleston Routes
Flight
Direct
Driving
Direct
Duration 1 hour 30 mins 10 hours
Avg Price $100-$300 $120-$250 in fuel
Operator American Airlines Personal Vehicle
Route MIA to CHS US-1 to I-95 N
Tip Check for direct flights from Fort Lauderdale (FLL) as an alternative to MIA. I-95 is the primary artery; watch for heavy traffic in the Savannah and Charleston metro areas.
Travel Tips
  • Airport Transit
    The CARTA bus service provides transport from the airport to downtown Charleston.
  • Traffic Planning
    Avoid the I-95 corridor during morning and evening rush hours.
  • Booking
    Book your flight at least 21 days in advance for better pricing.
  • Packing
    Bring comfortable walking shoes for exploring the city's many historic districts.
  • Navigation
    Use a real-time traffic app to navigate around construction on I-95.
Safety Tips
  • Hurricane Awareness
    Check weather reports for the South Carolina coast during the summer and autumn months.
  • Vehicle Prep
    Check your tire pressure before starting the long drive north.
  • City Safety
    Stay aware of your surroundings when walking in downtown areas at night.
  • Emergency Kit
    Keep a basic roadside kit in your car for long-distance travel.
People Also Ask
  • Is there a direct train to Charleston?
    Amtrak's Silver Service lines serve Charleston, but there is no direct rail from Florida.
  • How long is the drive to Charleston?
    The drive takes approximately 10 hours of pure transit time.
  • What is the best airport for Charleston?
    Charleston International Airport (CHS) is the main hub.
  • Is I-95 a good route?
    Yes, it is the most direct interstate highway connecting the South to South Carolina.
  • What should I see in Charleston?
    The Battery and the Historic District are top-rated attractions.
Quick Info
  • From Key Largo, Florida, United States
  • To Charleston, South Carolina, United States
  • Modes
Best Time to Travel

March to May for pleasant weather and blooming flowers in Charleston.

Things to Do in Charleston
1
The Battery
Visit this historic defensive seawall and promenade featuring beautiful mansions.
2
Historic District
Explore the largest National Historic Landmark District in the United States.
3
Charleston City Market
Enjoy this vibrant market featuring local food, crafts, and historic buildings.
4
Fort Sumter National Monument
Visit the site where the first shots of the Civil War were fired.
Tags
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