Driving
Key Largo to Jacksonville
Updated: 28 May 2026
The journey from Key Largo to Jacksonville covers approximately 600 kilometers. You will head north on the Florida Turnpike and then merge onto I-95 to reach the northernmost major city in Florida. The drive typically takes 6 to 7 hours depending on traffic. This route takes you the entire length of the Florida peninsula, from the tropical Keys to the Atlantic coast of North Florida.
Total Distance: 600 km driving distance; 580 km straight-line air distance.
Fastest Way
Driving via the Turnpike and I-95 is the fastest route, taking about 6.5 hours.
Cheapest Way
Driving your own vehicle is the most cost-effective method.
Compare Key Largo to Jacksonville Routes
Driving
Direct
Duration
6 hours 30 mins
Avg Price
$80-$100 in fuel
Operator
Personal Vehicle
Route
US-1 North to Florida Turnpike to I-95
I-95 can be very busy; plan for potential delays near major cities.
Travel Tips
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Toll RoadsThe Florida Turnpike has many tolls; use a SunPass.
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TrafficI-95 traffic can be heavy; check for accidents before you leave.
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ParkingDowntown Jacksonville has several public parking options.
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Sun ProtectionFlorida sun is strong; wear sunscreen and protective clothing.
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HydrationKeep water in your car for the long drive.
Safety Tips
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Road SafetyStay alert for heavy truck traffic on I-95.
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WeatherBe prepared for sudden rain showers, especially in the summer.
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EmergencyKeep your phone charged and have a roadside assistance plan.
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Vehicle MaintenanceCheck your car's condition before starting the long drive.
People Also Ask
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How long is the drive to Jacksonville?It takes about 6 to 7 hours depending on traffic.
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Are there tolls?Yes, the Florida Turnpike is a toll road.
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Is there a train?There is no direct train service from Key Largo to Jacksonville.
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What is the best route?The Florida Turnpike to I-95 is the most direct route.
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Can I take a bus?Private shuttle services are available but often require transfers.
Quick Info
- From Key Largo, Florida, United States
- To Jacksonville, Florida, United States
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Modes
Best Time to Travel
Spring and fall for mild weather.
Things to Do in Jacksonville
1
Cummer Museum of Art and Gardens
Visit this beautiful museum featuring a vast collection of art and stunning riverfront gardens.
2
Jacksonville Beach
Enjoy the wide sandy beaches and the vibrant pier area.
3
Riverside Arts Market
Explore this weekly market featuring local artists, food, and live music.
4
Catty Shack Ranch Wildlife Sanctuary
See rescued big cats in a safe and educational environment.
Tags
Key Largo to Jacksonville
driving to Jacksonville
Florida Turnpike to I-95
Jacksonville travel guide
Key Largo to Jacksonville distance
Florida road trip
long-distance driving
Florida travel
