Driving from Key Largo to Key West is one of the most iconic road trips in the United States. You will traverse the Overseas Highway, crossing 42 bridges over the turquoise waters of the Atlantic and the Gulf of Mexico. The route covers 155 kilometers and takes approximately 2.5 to 3 hours without stops. You will pass through Islamorada, Marathon, and Big Pine Key along the way. This journey is famous for its breathtaking ocean vistas and unique island culture.
Total Distance: 155 km driving distance; 150 km straight-line air distance.
Stop at the Seven Mile Bridge for the best photo opportunities.
March to May for pleasant temperatures and lower hurricane risk.