Is there a direct train to Naples?

No, there is no direct passenger rail service to Naples.

How long is the drive to Naples?

The drive takes approximately 2 hours and 30 minutes of pure transit time.

What is the best airport for Naples?

Southwest Florida International Airport (RSW) is the main hub.

Is the Tamiami Trail a good route?

Yes, it is the most direct and scenic highway connecting the Keys to Naples.

What should I see in Naples?

The Naples Pier and the Botanical Garden are top-rated attractions.

Key Largo

Naples

Driving

Key Largo to Naples

Updated: 28 May 2026

The journey from Key Largo to Naples covers approximately 180 kilometers. The most efficient way to travel is by driving west on the Tamiami Trail (US-41) through the Everglades. This route is a scenic drive through the heart of the Florida wilderness. Expect a transition from the tropical Keys to the upscale coastal environment of Naples.

Total Distance: 180 km driving distance; 150 km straight-line air distance.

Fastest Way

Driving via the Tamiami Trail (US-41).

Cheapest Way

Driving is the only practical way to travel between these two cities.

Compare Key Largo to Naples Routes

Driving

Direct

Duration

2 hours 30 mins

Avg Price

$20-$40 in fuel

Operator

Personal Vehicle

Route

US-1 to US-41 W

The Tamiami Trail is a scenic route; watch for wildlife crossing the road.

Travel Tips

Traffic Planning
Avoid the US-41 corridor during morning and evening rush hours.
Booking
Book your hotel at least 21 days in advance for better pricing.
Packing
Bring comfortable walking shoes for exploring the city's many districts.
Navigation
Use a real-time traffic app to navigate around construction on US-41.
Wildlife
Be cautious of wildlife crossing the road in the Everglades.

Safety Tips

Hurricane Awareness
Check weather reports for the Florida coast during the summer and autumn months.
Vehicle Prep
Check your tire pressure before starting the drive.
City Safety
Stay aware of your surroundings when walking in downtown areas at night.
Emergency Kit
Keep a basic roadside kit in your car for travel.