How long is the flight to San Diego?

The flight time is about 5.5 hours.

Is it better to fly or drive?

Flying is much faster and more practical.

Are there direct flights?

Yes, there are many direct flights from Miami to San Diego.

There is no direct train service from Key Largo to San Diego.

Key Largo

San Diego

Flight

Key Largo to San Diego

Updated: 28 May 2026

The distance from Key Largo to San Diego is approximately 4,200 kilometers. The most practical way to travel is to drive to Miami International Airport and take a flight to San Diego International Airport (SAN). Driving is possible but takes over 40 hours. San Diego is a major city known for its beaches, parks, and mild climate.

Total Distance: 4,200 km driving distance; 3,700 km straight-line air distance.

Fastest Way

Flying is the only practical way to travel this distance in a reasonable time.

Cheapest Way

Flying from Miami is the most cost-effective and time-efficient method.

Compare Key Largo to San Diego Routes

Flight

Direct

Duration

5 hours 30 mins (flight time)

Avg Price

$300-$600

Operator

American Airlines

Route

MIA to SAN

Book your flight in advance for the best prices.

Travel Tips

Airport Transport
Use ride-sharing or public transit to get to the airport in Miami.
Packing
Pack for the weather in San Diego, which can be very different from Florida.
Navigation
Use ride-sharing or a rental car to navigate San Diego easily.
Sun Protection
Even in San Diego, wear sunscreen during the summer.
Hydration
Stay hydrated while traveling.