Is there a train to Memphis?

No direct passenger rail service exists from Key West to Memphis.

How long is the drive?

The drive takes approximately 20 hours of pure road time.

Are there direct flights?

No, all flights from EYW to MEM require at least one connection.

What is the best highway?

I-75 is the primary interstate for the majority of the journey.

Is it safe to drive alone?

Yes, provided you plan your stops and stay on major interstates.

Key West

Memphis

Flight Driving

Key West to Memphis

Updated: 31 May 2026

The journey from Key West to Memphis spans approximately 1,900 kilometers. You will start by driving the Overseas Highway, US-1, through the Florida Keys. Most travelers fly from Key West International Airport (EYW) to Memphis International Airport (MEM) with a connection in Atlanta or Miami. Driving requires navigating I-75 North through Georgia and Alabama before reaching Tennessee. This route transitions from tropical island scenery to the rolling hills of the Mississippi Delta. Expect a significant climate shift as you move north.

Total Distance: 1,900 km driving, 1,550 km air distance.

Fastest Way

Flying is the fastest, taking roughly 5.5 hours including layovers.

Cheapest Way

Driving is the cheapest for groups of three or more people sharing fuel costs.

Compare Key West to Memphis Routes

	Flight Connecting	Driving Direct
Duration	5 hours 30 mins	20 hours
Avg Price	$350 - $600	$250 - $400 in fuel
Operator	American Airlines	Personal Vehicle
Route	EYW to MEM via MIA or ATL.	US-1 to I-95 N, then I-75 N and I-22 W.
Tip	Book flights at least three weeks in advance to secure lower fares.	Stop in Savannah for a break to avoid driver fatigue on the long stretch.

Travel Tips

Toll Roads
Carry a SunPass for Florida toll roads to save time and money.
Hydration
Keep water in your car during the long drive through Florida and Georgia.
Airport Parking
Use off-site parking at EYW to save on daily rates.
Traffic Alerts
Use navigation apps to avoid congestion in Atlanta during rush hour.
Packing
Pack layers as Memphis can be significantly cooler than Key West.

Safety Tips

Bridge Safety
Drive slowly on the Seven Mile Bridge during high winds.
Wildlife
Watch for deer on rural highways in Alabama and Tennessee at night.
Vehicle Check
Ensure your tires are inflated properly for the long-distance heat.
Emergency Kit
Keep a basic first aid kit and flashlight in your vehicle.