The drive from Kissimmee to Charleston covers approximately 650 kilometers, primarily via I-95 North and I-26 East. This journey takes about 6 to 7 hours. You will travel through the scenic coastal regions of Florida, Georgia, and South Carolina. Charleston, famous for its historic architecture and Southern charm, is a perfect destination for a weekend getaway.
Total Distance: Driving distance 650 km; straight-line air distance 550 km.
I-26 can be busy near Charleston; plan your arrival accordingly.
Spring and fall are the best times to visit, as the weather is mild and perfect for walking tours.