The journey from La Mesa to Chicago is a long-distance trip of over 2,700 km. Flying from San Diego International Airport (SAN) to O'Hare International Airport (ORD) is the most practical mode of transport. Driving is a multi-day journey across the country.
Total Distance: Driving distance 3,200 km; straight-line air distance 2,700 km.
United Airlines offers frequent direct flights.
Summer and early fall for pleasant weather.