The drive from Lago Vista to Amarillo is approximately 650 kilometers. You will take US-183 to US-281 North. The trip usually takes 6.5 to 7 hours. This route takes you across the vast landscape of the Texas Panhandle. Amarillo is a historic city on Route 66.
Total Distance: 650 km driving distance; 580 km straight-line air distance.
The drive is very long; plan for multiple stops.
Spring and fall are the most pleasant times to visit.