The drive from Land O' Lakes to Jacksonville takes about 3 hours and covers roughly 300 km. You will typically take I-75 N to I-10 E. This route takes you from the Tampa Bay area up to the historic city of Jacksonville on the Atlantic coast. Jacksonville is known for its riverfront and beautiful beaches.
Total Distance: Driving distance 300 km; Air distance 250 km.
The drive is straightforward but long; plan for stops.
March to May for perfect weather.