The drive from Laredo to San Antonio is a short 150-mile journey heading north on I-35. The drive takes approximately 2 hours and 30 minutes. This route is a major commercial corridor connecting the border to the heart of Texas. It is a straightforward drive through the brush country of South Texas.
Total Distance: 240 km driving distance; 230 km straight-line air distance.
Expect heavy truck traffic on I-35.
Spring and Fall offer the best weather for visiting San Antonio.