The drive from Lawrenceburg to Saint Louis covers approximately 400 kilometers. You will head west on US-50 to I-64 West, which leads directly into Saint Louis. This route takes roughly 4 hours of driving time. You will pass through the scenic landscapes of the rolling hills of Indiana and the flat plains of Illinois.
Total Distance: 400 km driving distance; 350 km straight-line air distance.
Traffic can be heavy on I-64 during rush hour.
Anytime, though morning and evening rush hours can be heavy in Saint Louis.