Flight
Driving
Lewes to St. Louis
Updated: 28 May 2026
The journey from Lewes to St. Louis is approximately 950 miles. You will primarily follow I-76 and I-70 West. This is a multi-day drive for most, taking about 15 hours of pure driving time. St. Louis is a major Midwestern hub, accessible via St. Louis Lambert International Airport.
Total Distance: 1,530 km driving distance; 1,250 km straight-line air distance.
Fastest Way
Flying is the fastest, saving you nearly 9 hours of travel time.
Cheapest Way
Driving is the most cost-effective for groups.
Compare Lewes to St. Louis Routes
|
Connecting
|
Direct
|
|
|---|---|---|
| Duration | 6 hours | 15 hours |
| Avg Price | $350-$600 | $180-$250 in fuel |
| Operator | Southwest Airlines | Personal Vehicle |
| Route | PHL to STL via Chicago or Baltimore. | DE-1 to I-95, I-76 West, and I-70 West. |
| Tip | Southwest often offers competitive rates into STL. | Plan for at least one overnight stop in Columbus or Indianapolis. |
Travel Tips
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Route ChoiceI-70 West is the most direct route across the country.
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Toll PrepKeep your E-ZPass for the Pennsylvania Turnpike.
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Airport TipSTL is a major hub; check for direct flights from BWI if PHL is expensive.
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Local TransitThe MetroLink light rail is great for getting between downtown and the airport.
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DiningTry St. Louis-style pizza and toasted ravioli.
Safety Tips
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Fatigue ManagementDo not attempt this drive in one day; stay overnight.
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Weather PrepCheck for severe weather alerts in the Midwest.
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Vehicle PrepCheck your tires and fluids before this long-distance trip.
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NavigationUse a GPS to navigate the I-70 corridor.
People Also Ask
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Is St. Louis worth visiting?Yes, it has world-class free attractions like the zoo and art museum.
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How long is the drive?Expect about 15 hours of driving time.
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Are there tolls?Yes, on the Pennsylvania Turnpike.
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What is the best way to get around?A car is best for the city, but the MetroLink is useful.
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Is the airport far?The airport is about 20 minutes from downtown.
Quick Info
- From Lewes, Delaware, United States
- To St. Louis, Missouri, United States
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Modes
Best Time to Travel
Spring and autumn for mild weather at the Gateway Arch.
Things to Do in St. Louis
1
Gateway Arch National Park
Visit the iconic arch and explore the museum beneath it.
2
Forest Park
A massive park home to the St. Louis Zoo, Art Museum, and Science Center.
3
City Museum
A unique, interactive playground built from repurposed industrial materials.
4
Anheuser-Busch Brewery
Take a tour of the historic brewery and see the famous Clydesdales.
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