Driving
Lewistown to Buffalo
Updated: 31 May 2026
The journey from Lewistown to Buffalo covers approximately 350 kilometers. The most direct route is driving via US-322 West and I-81 North, which takes you through the scenic Pennsylvania and New York countryside. This trip takes you from the rural mountains of Pennsylvania to the city of Buffalo on the shores of Lake Erie. The drive is a popular choice for those visiting the city.
Total Distance: 350 km driving distance; 300 km straight-line air distance.
Fastest Way
Driving is the fastest, taking about 4 hours.
Cheapest Way
Driving is the only practical option for this route.
Compare Lewistown to Buffalo Routes
Driving
Direct
Duration
4 hours
Avg Price
$35-$50 in fuel
Operator
Personal Vehicle
Route
US-322 West to I-81 North.
This is a straightforward and scenic route.
Travel Tips
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ParkingBuffalo has many parking garages; use apps to find deals.
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TrafficTraffic in Buffalo can be heavy.
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DiningTry a classic Buffalo wing.
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NavigationUse GPS to navigate the city.
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WeatherCheck for snow in winter.
Safety Tips
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DrivingBe prepared for heavy traffic in the city.
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Urban SafetyStay aware of your surroundings in busy areas.
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NavigationUse GPS to navigate the city.
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EmergencyKeep a cell phone charged.
People Also Ask
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Is there a train?No, there is no direct passenger rail service.
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How long is the drive?It takes about 4 hours.
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Is the drive easy?It is straightforward and scenic.
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Where is the station?There is no passenger train station in Buffalo.
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Are there tolls?No, this route is mostly toll-free.
Quick Info
- From Lewistown, Pennsylvania, United States
- To Buffalo, New York, United States
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Modes
Best Time to Travel
Summer is the best time to visit Buffalo for the lake activities.
Things to Do in Buffalo
1
Buffalo and Erie County Naval & Military Park
Explore the historic ships.
2
Albright-Knox Art Gallery
See world-class art collections.
3
Buffalo Zoo
Visit the local zoo.
4
Canalside
Enjoy the waterfront area.
Tags
Lewistown to Buffalo
I-81 to Buffalo
Pennsylvania to New York
Lewistown transport
Buffalo commute
best way to Buffalo
