Yes, Amtrak runs from Syracuse to Baltimore, but it requires a transfer.

How long is the drive?

The drive takes about 5.5 hours.

Yes, there are tolls on the I-95 portion of the route.

What is the best way to travel?

Driving is the most convenient way to make this trip.

Yes, it is a safe and well-maintained highway.

Liverpool

Baltimore

Driving

Liverpool to Baltimore

Updated: 30 May 2026

The journey from Liverpool, New York, to Baltimore, Maryland, covers approximately 325 miles. The most efficient driving route is taking I-81 South to I-95 South. This route takes you through the scenic Appalachian Mountains and into the historic city of Baltimore. Expect significant traffic when entering the Baltimore metropolitan area. The trip typically takes about 5.5 hours by car.

Total Distance: 520 km driving distance; 420 km straight-line air distance.

Fastest Way

Driving via I-81 South and I-95 South is the fastest and only practical way to make this trip.

Cheapest Way

Driving your own vehicle is the most cost-effective method.

Compare Liverpool to Baltimore Routes

Driving

Direct

Duration

5 hours 30 mins

Avg Price

$65 - $110 in fuel

Operator

Personal Vehicle

Route

I-81 S to I-95 S.

Use an E-ZPass for seamless toll payments on the I-95 corridor.

Travel Tips

Tolls
Be prepared for tolls on the I-95 corridor.
Traffic
Avoid driving into Baltimore during the morning and evening rush hours.
Parking
Parking is available in downtown garages; use parking apps to find deals.
Weather
Check the weather forecast, especially in winter, for snow warnings.
Navigation
Use a GPS to navigate the complex city streets.