Driving
Longwood to St. Louis
Updated: 01 Jun 2026
The drive from Longwood to St. Louis is a 1050-mile journey heading north and west. You will travel through Georgia, Tennessee, Kentucky, and Illinois before reaching Missouri. The drive takes approximately 16 hours, requiring an overnight stop. You will pass through major cities like Atlanta, Nashville, and Louisville. This route is a long-haul journey through the heart of the Midwest.
Total Distance: 1690 km driving distance; 1450 km straight-line air distance.
Fastest Way
Driving via I-75 and I-64 is the fastest route, taking 16 hours.
Cheapest Way
Driving your own vehicle is the most economical option at roughly 180 dollars.
Compare Longwood to St. Louis Routes
Driving
Direct
Duration
16 hours
Avg Price
180-210 USD
Operator
Personal Vehicle
Route
I-75 North to I-64 West.
Plan for at least one overnight stop.
Travel Tips
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TrafficAvoid the I-64 corridor during morning and evening rush hours in major cities.
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FuelGas prices are generally lower in the South than in the Midwest.
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NavigationUse a GPS to navigate the complex highway interchanges in the Midwest.
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WeatherBe prepared for heavy traffic in the Midwest region.
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Rest StopsUse the state welcome centers for clean facilities.
Safety Tips
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SpeedingState troopers are active on all interstate segments.
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FatigueDo not push through the 16-hour drive if you are tired.
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EmergencyKeep a well-stocked emergency kit in your vehicle.
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VisibilityUse headlights during rain, which is common in the East.
People Also Ask
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Is there a train to St. Louis?Amtrak serves St. Louis via the Lincoln Service line, but not from Florida.
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How long is the drive?It is about 16 hours of driving time.
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Are there tolls?Yes, there are some tolls on I-64 in the Midwest.
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Is I-64 safe?Yes, it is a major interstate highway.
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What is the best route?I-75 North to I-64 West is the standard route.
Quick Info
- From Longwood, Florida, United States
- To St. Louis, Missouri, United States
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Modes
Best Time to Travel
Summer or Fall for pleasant weather throughout the journey.
Things to Do in St. Louis
1
Gateway Arch
Visit the iconic monument. It is a must-see for visitors.
2
St. Louis Zoo
Explore a world-class zoo. It is a cultural highlight of the city.
3
Forest Park
Visit one of the best parks in the country. It is a beautiful place to walk.
4
City Museum
See a variety of exhibits in a beautiful setting. It is a great place for a family outing.
Tags
Longwood to St. Louis drive
I-75 to I-64 route
St. Louis travel guide
Missouri road trip
driving to St. Louis MO
Longwood to St. Louis distance
fastest way to St. Louis
Florida to Missouri drive
