The drive from Ludington to Indianapolis covers approximately 480 km and takes about 5 hours. The most direct route is via US-131 South to I-69 South, which takes you through Fort Wayne, Indiana. This is a major interstate route, making it efficient for long-distance travel. There is no practical public transit for this route, so driving is the recommended option.
Total Distance: 480 km by road, 420 km straight-line.
I-69 can have heavy truck traffic; maintain a safe following distance.
Spring or autumn for comfortable driving temperatures.