The drive from Mackinaw City to Ann Arbor is a 260-mile journey using I-75 and US-23. This route takes you through the heart of the Lower Peninsula. The drive takes approximately 4 hours. It is the most efficient way to travel between these two cities.
Total Distance: 418 km driving.
US-23 is a major highway with good speed limits.
Anytime, but autumn is beautiful with the fall colors.