The drive from Madison, Alabama to Columbus, Ohio spans approximately 850 km. You will travel north on I-65 and then transition to I-75 through Kentucky. The journey takes about 9 hours of driving time. You will pass through Nashville and Cincinnati. This route takes you from the Deep South into the heart of the Midwest.
Total Distance: Driving: 850 km. Air: 750 km.
Stop in Cincinnati for a quick visit to the riverfront.
May to September for pleasant weather and outdoor activities.