The route from Madison, Alabama to Jacksonville, Florida covers about 750 km. You will head south on I-65 toward Montgomery, then transition to I-10 East. The drive typically takes 8 hours under normal traffic conditions. You will cross through the scenic landscapes of Alabama and the Florida panhandle. This is a popular route for those heading to the Atlantic coast.
Total Distance: Driving: 750 km. Air: 650 km.
Stop in Tallahassee for a quick lunch break.
September to November for pleasant temperatures and fewer tourists.