The drive from Madison, Alabama to Kansas City, Missouri covers about 1,100 km. You will travel through Tennessee, Kentucky, and Missouri. The route primarily uses I-65, I-24, and I-70. The journey takes about 11 hours of driving time. You will pass through major cities like Nashville and St. Louis.
Total Distance: Driving: 1,100 km. Air: 950 km.
Stop in St. Louis for a break.
May to September for pleasant weather.