The drive from Marietta to St. Louis covers 850 kilometers, primarily using I-24 West and I-57 North. You will pass through Nashville and southern Illinois on your way to the Gateway City. The journey typically takes 9 hours, depending on traffic and stops. This route is a major artery connecting the Southeast to the Midwest. Expect varied terrain as you move from the Appalachian foothills to the flat plains of Illinois.
Total Distance: Driving distance 850 km, straight-line air distance 720 km.
The stretch through southern Illinois is very flat and can be monotonous.
Spring or early autumn for pleasant temperatures.