The drive from Medley to Naples covers about 180 kilometers. The most direct route is via I-75 North (Alligator Alley). You can expect a travel time of 2 to 2.5 hours depending on traffic. This route takes you from the industrial zone of Medley across the Everglades to the Gulf Coast city of Naples.
Total Distance: 180 km driving distance, 160 km straight-line air distance.
Alligator Alley is a toll road; ensure your SunPass is active.
Travel mid-day to avoid the heavy morning and evening rush hour traffic on I-75.