The drive from Melbourne to Jacksonville is a straightforward 160-mile journey north along Interstate 95. The trip typically takes 2 hours and 30 minutes, passing through the Space Coast and the St. Augustine area. This route is the primary artery for travel between Central and Northeast Florida. Traffic is generally manageable until you reach the Jacksonville metropolitan area.
Total Distance: 260 km driving distance; 240 km straight-line air distance.
St. Augustine is a great stop along the way for lunch.
Mid-week to avoid the heavy weekend traffic on I-95.