Is there a train to Chicago?

Amtrak's Southwest Chief runs from nearby Flagstaff to Chicago, but it is a long journey.

How long is the drive?

The drive is approximately 26 hours.

What is the best airport?

Chicago O'Hare (ORD) is the primary international hub.

Yes, the Illinois Tollway system is extensive.

Like any major city, exercise caution in certain neighborhoods.

Mesa

Chicago

Flight Driving

Mesa to Chicago

Updated: 28 May 2026

The journey from Mesa to Chicago covers approximately 2,800 kilometers. Driving takes about 26 hours, typically following I-40 East to I-55 North. Flying is the most practical method, with direct flights from Phoenix Sky Harbor to Chicago O'Hare International Airport. This route takes you through the heart of the American Midwest, crossing the Mississippi River. You will pass through major cities like Albuquerque, Oklahoma City, and St. Louis. Be prepared for significant weather changes, especially during winter months in the Midwest.

Total Distance: 2,800 km driving distance; 2,300 km straight-line air distance.

Fastest Way

Direct flight from PHX to ORD takes 3 hours 45 minutes.

Cheapest Way

Flying is significantly cheaper than the cost of fuel, hotels, and food for a multi-day drive.

Compare Mesa to Chicago Routes

	Flight Direct	Driving Direct
Duration	3 hours 45 mins	26 hours
Avg Price	$150-$400	$350-$500 in fuel
Operator	United Airlines	Personal Vehicle
Route	PHX to ORD	I-40 E to I-55 N.
Tip	O'Hare is a major hub, offering frequent flights from Phoenix.	The drive is long; plan for at least three days to ensure safety.

Travel Tips

Public Transit
The 'L' train system is the best way to navigate Chicago; get a Ventra card.
Deep Dish Pizza
Try the local specialty at a classic spot like Lou Malnati's or Giordano's.
Winter Weather
Chicago winters are harsh; pack heavy coats, gloves, and boots if visiting between November and March.
Architecture
Take an architecture boat tour on the Chicago River to see the city's famous skyline.
Airport Access
Use the Blue Line train to get from O'Hare to downtown quickly.

Safety Tips

Urban Awareness
Stick to well-populated areas, especially at night.
Winter Driving
If driving, ensure your car is equipped for snow and ice.
Vehicle Security
Do not leave anything visible in your car when parked on city streets.
Emergency Kit
Keep a winter emergency kit in your car if traveling during the colder months.