How long is the drive?

It typically takes 6 hours of driving time.

There are no major tolls on this route.

No, there is no direct passenger rail service to Amarillo.

What is the best way to travel?

Driving is the most reliable and flexible option.

Yes, Amarillo is a safe city, but practice standard urban safety precautions.

Mesquite

Amarillo

Driving

Mesquite to Amarillo

Updated: 31 May 2026

The journey from Mesquite to Amarillo covers approximately 600 kilometers, taking you north through the Texas Panhandle. The most direct route is via US-287 North, which takes about 6 hours. This route is a classic Texas road trip, passing through several historic towns. Ensure your vehicle is prepared for the long, open stretches of highway.

Total Distance: 600 km driving distance; 560 km straight-line air distance.

Fastest Way

Driving is the fastest method for this route.

Cheapest Way

Driving is the most cost-effective and practical way to reach Amarillo.

Compare Mesquite to Amarillo Routes

Driving

Direct

Duration

6 hours

Avg Price

65-90 USD in fuel

Operator

Personal Vehicle

Route

US-287 North to Amarillo.

Watch your speed in small towns along US-287; speed limits change frequently.

Travel Tips

Fuel Stops
Plan your fuel stops in larger towns like Wichita Falls or Childress.
Hydration
The air is very dry; keep plenty of water in your vehicle.
Navigation
Download offline maps as cell service can be intermittent in rural areas.
Weather
Be prepared for sudden wind storms that can reduce visibility.
Planning
Check for local events in Amarillo that might affect hotel availability.

Safety Tips

Highway Safety
Stay alert for agricultural vehicles on rural roads.
Emergency Kit
Keep a well-stocked emergency kit in your car for the 600 km drive.
Night Driving
Avoid driving at night if possible, as wildlife is active on the roads.
Communication
Ensure your phone is charged and you have a backup power bank.