The journey from Mobridge to Birmingham covers approximately 1,400 miles. You will travel south through South Dakota, Iowa, Missouri, Illinois, Kentucky, and Tennessee before reaching Alabama. The route primarily uses I-29, I-64, and I-65. This trip typically takes 22 hours of driving time. You will pass through major cities like Kansas City, St. Louis, and Nashville.
Total Distance: 2,250 km driving distance; 1,800 km straight-line air distance.
I-65 South provides a direct route into Birmingham from Nashville.
Spring or fall for comfortable weather in Birmingham.