No, there is no direct train service to Des Moines.

Yes, it is a standard highway route with regular traffic.

Yes, Des Moines has many lodging options for travelers.

Summer and fall are best to avoid extreme winter weather.

Mobridge

Des Moines

Driving

Mobridge to Des Moines

Updated: 31 May 2026

The drive from Mobridge to Des Moines is a 400-mile journey across the plains of South Dakota and Iowa. You will head east and south, eventually joining I-35 for the final stretch. This route takes you through the heart of the region's agricultural landscape. The drive takes approximately 6 hours.

Total Distance: Driving distance 640 km; straight-line air distance 500 km.

Fastest Way

Driving via US-12 and I-35 takes approximately 6 hours.

Cheapest Way

Driving your own vehicle is the most practical and cost-effective option.

Compare Mobridge to Des Moines Routes

Driving

Direct

Duration

6 hours

Avg Price

$60 - $90 (fuel)

Operator

Personal Vehicle

Route

US-12 E to I-35 S.

Enjoy the scenic transition from rural plains to the city.

Travel Tips

Fuel Stops
Gas up in Mobridge or Des Moines; services are available along the route.
Speed Limits
Be aware of changing speed limits in small towns along the route.
Hydration
Keep water in your car, especially during the summer months.
Timing
Avoid driving at night to minimize the risk of hitting wildlife.
Snacks
Pack a cooler, as dining options are sparse between towns.

Safety Tips

Wildlife
Watch for deer and other wildlife, especially during dawn and dusk.
Vehicle Prep
Check your tire pressure before leaving.
Communication
Cell service can be intermittent; download your route for offline use.
Emergency Kit
Carry a basic tool kit and a spare tire in good condition.