Flight
Driving
Mount Pleasant to Key West
Updated: 28 May 2026
The journey from Mount Pleasant to Key West covers approximately 700 miles. You can drive via I-95 South and the Overseas Highway, which takes about 12 hours, or fly from Charleston International Airport (CHS) to Key West International Airport (EYW), which takes about 4 hours with connections. This route connects the South Carolina coast to the tropical island of Key West.
Total Distance: 1,100 km driving distance, 1,000 km straight-line air distance.
Fastest Way
Flying is the fastest method.
Cheapest Way
Driving is often cheaper if traveling with multiple people.
Compare Mount Pleasant to Key West Routes
|
Connecting
|
Direct
|
|
|---|---|---|
| Duration | 4 hours | 12 hours |
| Avg Price | $250-$500 | $150-$200 in fuel |
| Operator | American Airlines | Personal Vehicle |
| Route | CHS to EYW | I-95 South to Overseas Highway |
| Tip | Book well in advance for the best fares. | The drive through the Florida Keys is very scenic. |
Travel Tips
-
Public TransitUse the Duval Loop bus to get around.
-
WalkingKey West is very walkable.
-
DiningTry the local key lime pie.
-
WeatherKey West weather is tropical; pack light.
-
TransportationRenting a bike is recommended in Key West.
Safety Tips
-
City AwarenessStay in well-populated areas, especially at night.
-
Public TransitKeep your belongings secure on the bus.
-
DrivingBe prepared for heavy traffic on the Overseas Highway.
-
EmergencyKnow the location of the nearest hospital.
People Also Ask
-
Is there a train?No, there is no train service to Key West.
-
How long is the flight?The flight is about 4 hours.
-
Is it better to fly or drive?Flying is much better.
-
Are there tolls?Yes, there are tolls on some highways.
-
What is the best airport?EYW is the main airport.
Quick Info
- From Mount Pleasant, South Carolina, United States
- To Key West, Florida, United States
-
Modes
Best Time to Travel
Winter or Spring for pleasant weather.
Things to Do in Key West
1
Duval Street
Enjoy the famous nightlife and shops.
2
Ernest Hemingway Home
Tour the historic home of the famous author.
3
Mallory Square
Watch the sunset and street performers.
4
Dry Tortugas National Park
Take a boat trip to the remote park.
Tags
Mount Pleasant to Key West
Charleston to Key West travel
flights to Key West
driving to Key West
SC to FL travel
best way to Key West
travel guide SC to Florida
transportation options
