The drive from Muskegon Heights to Louisville is approximately 600 kilometers and takes about 6 hours. You will primarily use I-65 South. This route takes you through the heart of Indiana and into Kentucky. It is a major interstate corridor connecting the Great Lakes region to the South. Expect moderate traffic as you approach the Louisville metropolitan area.
Total Distance: 600 km driving distance; 550 km straight-line air distance.
I-65 can be busy; use a navigation app for traffic updates.
May for the Kentucky Derby or September for pleasant weather.