The drive from Nags Head to Charlotte is a 350-mile journey across North Carolina. You will take US-64 West to I-85 South. The trip typically takes about 6 hours, depending on traffic in the Raleigh and Charlotte metro areas. This route connects the coast to the largest city in the state.
Total Distance: 560 km driving distance; 480 km straight-line air distance.
I-85 can be very busy near Charlotte.
Spring or Fall to enjoy the mild weather in both regions.