The drive from New Smyrna Beach to Key West is a 400-mile journey south through the Florida Keys. You will primarily take the Florida Turnpike and US-1 South. The trip typically takes 7 to 8 hours depending on traffic. This route offers a scenic transition from the central Florida coast to the tropical paradise of the Florida Keys.
Total Distance: 650 km driving distance; 550 km straight-line air distance.
Expect heavy traffic in the Miami and Florida Keys corridors.
Winter or Spring for the best weather in the Florida Keys.