New Smyrna Beach
New Smyrna Beach
Key West
Key West
Driving

New Smyrna Beach to Key West

Updated: 28 May 2026

The drive from New Smyrna Beach to Key West is a 400-mile journey south through the Florida Keys. You will primarily take the Florida Turnpike and US-1 South. The trip typically takes 7 to 8 hours depending on traffic. This route offers a scenic transition from the central Florida coast to the tropical paradise of the Florida Keys.

Total Distance: 650 km driving distance; 550 km straight-line air distance.
Fastest Way
Driving is the fastest and most practical method for this distance.
Cheapest Way
Driving your own vehicle is the most economical way to travel.
Compare New Smyrna Beach to Key West Routes
Driving
Direct
Duration
7 hours 30 mins
Avg Price
$70-$100 in fuel
Operator
Personal Vehicle
Route
Florida Turnpike to US-1 S.

Expect heavy traffic in the Miami and Florida Keys corridors.

Travel Tips
  • Traffic
    Avoid driving in Miami during rush hour; traffic can be heavy.
  • Parking
    Use public parking garages in Key West to avoid street parking fines.
  • Dining
    Make dinner reservations well in advance for popular Key West restaurants.
  • Walking
    Key West is a very walkable city; wear comfortable shoes.
  • Weather
    Be prepared for humidity in the summer months.
Safety Tips
  • Speeding
    Be cautious of speed traps in the Florida Keys.
  • Tires
    Check your tire pressure before leaving, as Florida heat can affect them.
  • Emergency
    Keep a charged phone and a physical map in case of signal loss.
  • Rest
    Take breaks every 2 hours to stay alert while driving.
People Also Ask
  • How long is the drive?
    The drive takes approximately 7.5 hours.
  • What is the best route?
    US-1 South is the only route through the Florida Keys.
  • Are there tolls?
    There are tolls on the Florida Turnpike.
  • Is it a scenic drive?
    Yes, the drive through the Florida Keys is very scenic.
  • What should I see in Key West?
    Duval Street, Hemingway Home, and Southernmost Point are must-sees.
Quick Info
  • From New Smyrna Beach, Florida, United States
  • To Key West, Florida, United States
  • Modes
Best Time to Travel

Winter or Spring for the best weather in the Florida Keys.

Things to Do in Key West
1
Duval Street
Explore the famous street for nightlife and dining.
2
Ernest Hemingway Home
Visit the historic home of the famous author.
3
Southernmost Point
Take a photo at the iconic landmark.
4
Mallory Square
Watch the sunset and enjoy the street performers.
Tags
New Smyrna Beach to Key West driving to Key West Florida Keys road trip Florida travel Key West guide best route to Key West road trip tips New Smyrna Beach transport