Is there a direct train?

No, there is no direct passenger rail service from North Little Rock to St. Louis.

How long is the bus ride?

The bus ride typically takes 8 hours including transfers.

Like any major city, stick to tourist-friendly areas and remain aware of your surroundings.

What is the best route?

US-67 N is the most direct driving route.

There are no major toll roads on the direct route from NLR to St. Louis.

North Little Rock

St. Louis

Bus Driving

North Little Rock to St. Louis

Updated: 28 May 2026

The route from North Little Rock to St. Louis spans approximately 380 miles, primarily following US-67 North through the Missouri bootheel. Driving is the most efficient mode, usually taking about 5.5 to 6 hours. You will pass through scenic rural landscapes and small towns like Poplar Bluff before reaching the St. Louis metro area. Alternatively, bus services provide a budget-friendly option for those not wishing to drive. The journey connects the Arkansas River Valley to the confluence of the Mississippi and Missouri Rivers.

Total Distance: 610 km driving distance; 530 km straight-line air distance.

Fastest Way

Driving is the fastest method, taking under 6 hours compared to 8+ hours by bus.

Cheapest Way

Driving is the cheapest option for groups, while bus travel is cost-effective for solo travelers.

Compare North Little Rock to St. Louis Routes

	Bus Connecting	Driving Direct
Duration	8 hours	5 hours 45 mins
Avg Price	$70-$110	$60-$80 in fuel
Operator	Greyhound	Personal Vehicle
Route	Little Rock Station to St. Louis Gateway Station.	US-67 N to I-55 N.
Tip	Book at least two weeks in advance for the lowest fares.	US-67 has several speed traps in small towns; maintain posted limits.

Travel Tips

Traffic
Avoid the I-55/I-64 interchange in downtown St. Louis during morning and evening rush hours.
Public Transit
Use the MetroLink light rail system to navigate between major attractions without a car.
Dining
Try the local St. Louis-style pizza, known for its thin crust and Provel cheese.
Safety
Stay in well-lit, populated areas when exploring downtown at night.
Weather
Check the forecast for the Mississippi River valley, as weather can change rapidly.

Safety Tips

Highway Safety
Be alert for heavy semi-truck traffic on I-55.
Vehicle Security
Do not leave valuables in your car when parked in urban areas.
Navigation
Use a GPS with real-time traffic updates to avoid construction delays.
Emergency
Keep an emergency kit in your trunk, including water and a flashlight.