Yes, I-22 is a modern interstate that provides a very smooth drive.

Are there direct flights?

No, you will need to connect through a hub like Charlotte or Dallas.

How long is the drive?

The drive takes approximately 9 hours.

What is the best time to visit?

Spring and Fall are the most pleasant seasons.

Is Birmingham walkable?

Downtown is walkable, but a car is recommended for exploring the suburbs.

O'Fallon

Birmingham

Flight Driving

O'Fallon to Birmingham

Updated: 28 May 2026

The trip from O'Fallon to Birmingham is a straightforward journey south through the heart of the Mississippi River valley. Driving is the most popular method, taking about 8 to 9 hours via I-55 South to Memphis, then I-22 East directly into Birmingham. Flying from St. Louis Lambert (STL) to Birmingham-Shuttlesworth International Airport (BHM) is also an option, though it usually involves a connection. This route takes you through the historic landscapes of the Deep South.

Total Distance: 850 km driving, 720 km air distance.

Fastest Way

Flying is faster, with a total travel time of about 4-5 hours including the layover.

Cheapest Way

Driving is significantly cheaper than flying for this distance.

Compare O'Fallon to Birmingham Routes

	Flight Connecting	Driving Direct
Duration	4 hours	9 hours
Avg Price	$200-$400	$100-$150
Operator	American Airlines	Personal Vehicle
Route	STL to BHM via CLT or DFW.	I-55 South to Memphis, then I-22 East to Birmingham.
Tip	Flights are quick but require a layover in a major hub.	I-22 is a modern, well-maintained highway that makes the final leg very efficient.

Travel Tips

Memphis Traffic
Be prepared for potential congestion when passing through Memphis on I-55.
Dining
Try the famous Alabama-style barbecue while in Birmingham.
Booking
Book flights at least two weeks in advance for better pricing.
Navigation
Use GPS to navigate the I-22 to I-65 interchange in Birmingham.
Rest Stops
There are plenty of service stations along the I-22 corridor.

Safety Tips

Speed Limits
Observe speed limits strictly, especially in small towns along the route.
Weather
Check for severe weather alerts, as the region is prone to thunderstorms.
Vehicle Prep
Ensure your tires are properly inflated for the long highway drive.
Night Driving
Avoid driving through rural sections of the route late at night.