Yes, I-40 is a major interstate that is well-maintained.

Are there direct flights?

No, you will need to connect through a hub like Dallas or Charlotte.

How long is the drive?

The drive takes approximately 7 hours.

What is the best time to visit?

Spring and Fall are the most pleasant seasons.

Is Little Rock walkable?

Downtown and the River Market area are very walkable.

O'Fallon

Little Rock

Flight Driving

O'Fallon to Little Rock

Updated: 28 May 2026

The journey from O'Fallon to Little Rock is a direct drive south through Missouri and into Arkansas. The most efficient route is taking I-55 South to Memphis, then transitioning to I-40 West into Little Rock. The drive covers approximately 450 miles and takes about 7 hours. Flying from St. Louis Lambert (STL) to Clinton National Airport (LIT) is also possible, though it typically requires a connection. This route offers a scenic drive through the Ozark foothills and the Mississippi Delta.

Total Distance: 720 km driving, 600 km air distance.

Fastest Way

Flying is faster, with a total travel time of about 4-5 hours including the layover.

Cheapest Way

Driving is the most cost-effective option for this trip.

Compare O'Fallon to Little Rock Routes

	Flight Connecting	Driving Direct
Duration	4 hours	7 hours
Avg Price	$200-$400	$80-$120
Operator	American Airlines	Personal Vehicle
Route	STL to LIT via DFW or CLT.	I-55 South to Memphis, then I-40 West to Little Rock.
Tip	Flights are convenient but usually require a layover.	The I-40 stretch between Memphis and Little Rock is flat and easy to navigate.

Travel Tips

Memphis Traffic
Try to avoid the Memphis bridge crossing during peak rush hours.
Dining
Sample local Arkansas catfish at restaurants along the river.
Booking
Book flights early to avoid high last-minute prices.
Navigation
Use GPS to navigate the I-40/I-30 interchange in Little Rock.
Rest Stops
There are numerous rest areas along I-40 for your convenience.