O'Fallon
O'Fallon
New Orleans
New Orleans
Flight Driving

O'Fallon to New Orleans

Updated: 28 May 2026

The trip from O'Fallon to New Orleans covers about 700 miles. Driving via I-55 takes approximately 11 hours. You will travel through the Mississippi River valley. Alternatively, you can fly from St. Louis (STL) to New Orleans (MSY) in about 2 hours.

Total Distance: 1,130 km driving distance; 980 km straight-line air distance.
Fastest Way
Flying is the fastest, taking 2 hours.
Cheapest Way
Driving is the most cost-effective for groups.
Compare O'Fallon to New Orleans Routes
Flight
Direct
Driving
Direct
Duration 2 hours 11 hours
Avg Price 150-400 USD 130-180 USD
Operator Southwest Airlines Personal Vehicle
Route STL to MSY I-55 S
Tip Book early for the best rates to New Orleans. Expect heavy traffic in Memphis and New Orleans.
Travel Tips
  • Traffic
    New Orleans traffic can be heavy; plan your travel accordingly.
  • Walking
    The French Quarter is best explored on foot.
  • Airport
    MSY is busy; arrive at least 2 hours before your flight.
  • Dining
    Try authentic Creole and Cajun cuisine.
  • Navigation
    Use a GPS to navigate the city streets.
Safety Tips
  • Driving
    Stay alert on long stretches of I-55.
  • Weather
    Be prepared for sudden thunderstorms.
  • City Safety
    Stick to well-lit areas in tourist districts.
  • Emergency
    Keep a roadside assistance contact handy.
People Also Ask
  • How long is the drive?
    The drive takes about 11 hours.
  • Is New Orleans walkable?
    The French Quarter is, but other areas require transport.
  • Are there tolls?
    Some bridges in Louisiana have tolls.
  • What is the best time to visit?
    Spring and fall are ideal.
  • Is it a safe drive?
    Yes, the interstate route is safe.
Quick Info
  • From O'Fallon, Missouri, United States
  • To New Orleans, Louisiana, United States
  • Modes
Best Time to Travel

February to May or October to December for mild weather.

Things to Do in New Orleans
1
French Quarter
Explore the historic heart of the city with its unique architecture and jazz clubs.
2
Garden District
Walk through this neighborhood known for its beautiful mansions and oak-lined streets.
3
National WWII Museum
Visit this world-class museum dedicated to the history of the second world war.
4
Jackson Square
Enjoy street performers and artists in this iconic public square.
Tags
O'Fallon to New Orleans driving to Louisiana I-55 route flights from STL to MSY Missouri to New Orleans New Orleans travel guide road trip to Louisiana best way to New Orleans