Flight
Driving
O'Fallon to Tampa
Updated: 28 May 2026
The trip from O'Fallon to Tampa covers about 1,100 miles. Driving via I-64 and I-75 takes approximately 17 hours. You will travel through the Southeast and into the Gulf Coast of Florida. Alternatively, you can fly from St. Louis (STL) to Tampa (TPA) in about 2 hours and 45 minutes.
Total Distance: 1,770 km driving distance; 1,550 km straight-line air distance.
Fastest Way
Flying is the fastest, taking less than 3 hours.
Cheapest Way
Driving is the most cost-effective for groups.
Compare O'Fallon to Tampa Routes
|
Direct
|
Direct
|
|
|---|---|---|
| Duration | 2 hours 45 mins | 17 hours |
| Avg Price | 180-450 USD | 200-270 USD |
| Operator | Southwest Airlines | Personal Vehicle |
| Route | STL to TPA | I-64 E to I-75 S |
| Tip | Book early for the best rates to Tampa. | Expect heavy traffic in Atlanta and through Florida. |
Travel Tips
-
TrafficTampa traffic can be heavy; plan your travel accordingly.
-
Sun ProtectionFlorida sun is intense; wear sunscreen daily.
-
AirportTPA is very busy; arrive at least 2 hours before your flight.
-
DiningTry a Cuban sandwich at a local restaurant.
-
NavigationUse a GPS to navigate the complex highway system.
Safety Tips
-
DrivingStay alert on long stretches of I-75.
-
WeatherBe prepared for sudden afternoon thunderstorms.
-
City SafetyStick to well-lit areas in tourist districts.
-
EmergencyKeep a roadside assistance contact handy.
People Also Ask
-
How long is the drive?The drive takes about 17 hours.
-
Is Tampa walkable?Parts of the city are, but a car is recommended.
-
Are there tolls?Yes, many Florida highways are toll roads.
-
What is the best time to visit?Winter is the best time.
-
Is it a safe drive?Yes, the interstate route is safe.
Quick Info
- From O'Fallon, Missouri, United States
- To Tampa, Florida, United States
-
Modes
Best Time to Travel
December to April for the best weather.
Things to Do in Tampa
1
Busch Gardens
Visit this popular theme park known for its roller coasters and animal exhibits.
2
The Florida Aquarium
Explore marine life exhibits in the heart of downtown Tampa.
3
Ybor City
Walk through this historic district famous for its cigar history and nightlife.
4
Riverwalk
Enjoy a scenic walk along the Hillsborough River with views of the city.
Tags
O'Fallon to Tampa
driving to Florida
I-75 route
flights from STL to TPA
Missouri to Tampa
Tampa travel guide
road trip to Florida
best way to Tampa
