The drive from Orange Beach to Chicago covers 1500 kilometers. You will travel north on I-65 through Alabama, Tennessee, Kentucky, Indiana, and into Illinois. The journey takes about 15 hours. You will pass through Birmingham, Nashville, Louisville, and Indianapolis. This route is the most efficient way to reach the windy city of Chicago.
Total Distance: 1500 km driving distance; 1300 km straight-line air distance.
Traffic near Chicago can be heavy.
Spring and Fall for pleasant weather.