The drive from Orange Beach to Indianapolis covers 1200 kilometers. You will travel north on I-65 through Alabama, Tennessee, Kentucky, and into Indiana. The journey takes about 12 hours. You will pass through Birmingham, Nashville, and Louisville. This route is the most efficient way to reach the racing city of Indianapolis.
Total Distance: 1200 km driving distance; 1050 km straight-line air distance.
Traffic near Indianapolis can be heavy.
Spring and Fall for pleasant weather.