The drive from Orange Beach to San Antonio covers 1100 kilometers. You will travel west on I-10 through Alabama, Mississippi, Louisiana, and into Texas. The journey takes about 11 hours. You will pass through Mobile, Baton Rouge, and Houston. This route is the most efficient way to reach the historic city of San Antonio.
Total Distance: 1100 km driving distance; 950 km straight-line air distance.
Traffic near Houston and San Antonio can be heavy.
Spring and Fall for pleasant weather.