The drive from Orange Beach to San Francisco covers 4200 kilometers. You will travel west on I-10 and then north on I-5. The journey takes about 42 hours. You will pass through Mobile, Baton Rouge, Houston, San Antonio, El Paso, Phoenix, and Los Angeles. This route is the most efficient way to reach the golden city of San Francisco.
Total Distance: 4200 km driving distance; 3700 km straight-line air distance.
Traffic near major cities can be heavy.
Spring and Fall for pleasant weather.