The drive from Orange Beach to Tampa covers 750 kilometers. You will travel east on I-10 and then south on I-75. The journey takes about 7.5 hours. You will pass through Tallahassee and Ocala. This route is the most efficient way to reach the coastal city of Tampa.
Total Distance: 750 km driving distance; 650 km straight-line air distance.
Traffic near Tampa can be heavy.
Spring and Fall for pleasant weather.