The trip from Orangeburg to Nashville spans 450 miles through the Appalachian foothills. You will take I-26 West through Asheville before connecting to I-40 West. This route offers stunning mountain scenery, especially through the Blue Ridge Mountains. Nashville, known as Music City, is a vibrant destination for culture and history.
Total Distance: 720 km driving distance; 600 km straight-line air distance.
The mountain passes on I-26 can be foggy; drive with headlights on.
May to October for pleasant weather and outdoor music festivals.