The journey from Orchard Park to Syracuse is approximately 150 miles. Driving via I-90 E is the most efficient route, taking about 2 hours and 15 minutes. This route takes you across the scenic landscape of Upstate New York. It is a straightforward drive along the New York State Thruway.
Total Distance: 240 km driving, 210 km air distance.
The New York State Thruway requires tolls; use an E-ZPass.
Summer and early autumn for pleasant driving conditions and scenic views.