Oxford
Oxford
Nashville
Nashville
Driving

Oxford to Nashville

Updated: 30 May 2026

The drive from Oxford to Nashville covers approximately 450 kilometers and takes about 4.5 hours. You will typically travel east on MS-6 to I-22 E, then connect to I-65 N. This route takes you through the scenic hills of North Mississippi and into Tennessee. It is a popular path for those visiting the music capital of the world.

Total Distance: Driving distance 450 km, straight-line air distance 380 km.
Fastest Way
Driving via I-22 E and I-65 N is the fastest route.
Cheapest Way
Driving your own vehicle is the most practical and cheapest option.
Compare Oxford to Nashville Routes
Driving
Direct
Duration
4 hours 30 mins
Avg Price
$50 - $70 in fuel
Operator
Personal Vehicle
Route
MS-6 E to I-22 E to I-65 N

I-22 is a major highway connecting Mississippi to Alabama and Tennessee.

Travel Tips
  • Route Choice
    I-22 E is the most efficient highway; follow signs for Birmingham then Nashville.
  • Traffic
    Nashville traffic can be heavy; check maps before entering the city.
  • Rest Stops
    There are many stops along I-22 and I-65.
  • Planning
    Check for road construction updates on state transportation websites.
  • Timing
    Try to arrive in Nashville outside of peak rush hours.
Safety Tips
  • Speeding
    Police monitor speed limits on I-22 and I-65; stay within limits.
  • Night Driving
    Be cautious of wildlife on rural sections of the highway.
  • Vehicle Prep
    Ensure your vehicle is in good condition for a 4.5-hour drive.
  • Emergency
    Keep a mobile phone charged and have a roadside assistance plan.
People Also Ask
  • How long is the drive to Nashville?
    It takes about 4.5 hours to drive from Oxford to Nashville.
  • Is there a train to Nashville?
    No, there is no passenger rail service between Oxford and Nashville.
  • What is the best route?
    Taking I-22 E to I-65 N is the most direct route.
  • Are there tolls?
    No, there are no toll roads on this route.
  • Is it a safe drive?
    Yes, it is a standard, safe highway drive.
Quick Info
  • From Oxford, Mississippi, United States
  • To Nashville, Tennessee, United States
  • Modes
Best Time to Travel

Spring or Fall for comfortable weather in Nashville.

Things to Do in Nashville
1
Grand Ole Opry
The world-famous stage for country music. It is a must-visit for any music lover.
2
Country Music Hall of Fame
A massive museum dedicated to the history and stars of country music.
3
Ryman Auditorium
The historic home of the Grand Ole Opry, known for its incredible acoustics.
4
Broadway Honky Tonks
A vibrant street filled with live music venues, bars, and restaurants.
Tags
Oxford to Nashville drive I-22 E route Nashville travel guide driving distance Oxford to Nashville Tennessee travel Oxford MS to Nashville TN best way to travel to Nashville Nashville attractions