How long is the drive?

It typically takes about 6 hours.

There is no passenger train service to Amarillo.

What is the best route?

US-87 is the most direct route.

No, there are no tolls on this route.

Ozona

Amarillo

Driving

Ozona to Amarillo

Updated: 28 May 2026

The drive from Ozona to Amarillo covers approximately 350 miles north through the heart of West Texas. The primary route is via US-87, which offers a scenic and straightforward journey across the plains. You will pass through several small towns, including San Angelo and Lubbock, before arriving in Amarillo. The drive typically takes about 6 hours. Amarillo is known for its proximity to Palo Duro Canyon and the Cadillac Ranch.

Total Distance: 560 km driving distance; 550 km straight-line air distance.

Fastest Way

Driving via US-87 is the fastest route, offering a consistent speed limit and fewer traffic lights.

Cheapest Way

Driving your own vehicle is the most cost-effective method, costing roughly 60 dollars in fuel.

Compare Ozona to Amarillo Routes

Driving

Direct

Duration

360 minutes

Avg Price

55-65 USD

Operator

Personal Vehicle

Route

US-87 North to Amarillo.

Be prepared for long stretches of open road with limited services.

Travel Tips

Fueling
Fill up in Ozona, San Angelo, and Lubbock, as gas stations can be sparse in between.
Traffic Planning
Traffic is generally light, but watch for agricultural vehicles on rural roads.
Parking
Most attractions in Amarillo have ample free parking.
Hydration
Carry water, as the West Texas heat can be intense.
Navigation
Use GPS to navigate, but be aware that cell service can be spotty in rural areas.

Safety Tips

Speed Limits
Adhere to speed limits, especially when entering small towns.
Weather Alerts
Check for local weather advisories, especially during thunderstorm season.
Vehicle Check
Ensure your car is in good condition for the 350-mile drive.
Emergency
Keep a list of local emergency contacts in your glove box.