The drive from Panama City Beach to Las Vegas is approximately 2,200 miles and takes about 32 hours. You will travel west along the Gulf Coast and through the Southwest via I-10 and I-15. This route takes you from the beaches of Florida to the entertainment capital of the world.
Total Distance: Driving distance 3,500 km; straight-line air distance 2,800 km.
This is a very long drive; plan for multiple overnight stops.
Spring or Fall for pleasant weather.