The drive from Panama City Beach to Los Angeles is approximately 2,400 miles and takes about 35 hours. You will travel west along the Gulf Coast and through the Southwest via I-10. This route takes you from the beaches of Florida to the city of angels.
Total Distance: Driving distance 3,800 km; straight-line air distance 3,000 km.
This is a very long drive; plan for multiple overnight stops.
Spring or Fall for pleasant weather.