The distance from Pembroke Pines to Key West is about 260 km. The most direct and scenic route is via the Overseas Highway (US-1). This trip takes about 4 hours and offers stunning views of the ocean. Key West is famous for its laid-back atmosphere and historic sites.
Total Distance: 260 km driving distance; 230 km straight-line air distance.
The Overseas Highway is a single-lane road in many places; traffic can be slow.
Year-round, but avoid hurricane season.